Tag: ciracas.id

Antihyperglycemic Activity of Ethanolic Herb Extract of Ceplukan(Physalis angulata L.) in Diabetic Hypercholesterolemia in Male Hamsters

Diabetes mellitus is a disease characterized by hyperglycemia as well as progressive changes to the
pancreatic beta cell structure. This study was conducted to determine the antihyperglycemic activity of
ceplukan herb extract (Physalis angulata L.) in alloxan-induced male Syrian hamsters and high cholesterol
feed. The study used 24 hamsters divided into six groups. Group I were given a standard diet and regular
drinking water, Group II were given metformin dose 61,66 mg/kg body weight (BW), Group III were
alloxan-induced and high cholesterol feed, Groups IV, V and VI were given extract dose 60, 120 and 240
mg/kg BW respectively. The animals were induced alloxan monohydrate as well as were given high
cholesterol feed during treatment. Blood sampling was performed on the 29th and 44th day using a clinical
spectrophotometer. The results show significant differences between treatment groups (α <0,05), followed
by Tukey test. In conclusion, the preparation of herbal extract test ceplukan at doses of 120 and 240 mg/kg
BW could reduce blood glucose levels by 50.84% and 43.41% which is equivalent to metformin dose of
61.66 mg/kg BW with a percentage of 53.12%.

Determination of LC50 value of Nicotiana tabacum L. extract against Gryllus bimaculatus imago and Galleria mellonella larvae

Replacement of synthetic pesticide with natural pesticide is highly demanding because it is more
environmentally friendly. Tobacco is majorly exploited for cigarettes production. Therefore, it needs to be developed for
other alternative products, one of which is insecticide due to nicotine content and other toxic compounds. This research
aimed to determine the effectiveness of tobacco as an insecticide for Galleria mellonella and Gryllus bimaculatus. The
raw material used in this study was the leaf extract of Nicotiana tabacum L., var. Virginia that was obtained by Ethanolic
Heat Reflux Extraction (EHRE) technique. After testing on the insects, LC50 values were 36.6 mg/ml for Galleria
mellonella and 38.5 mg/ml for Gryllus bimaculatus.