Acute Oral Toxicity Test of Nicotiana tabacum L. Bio-Oil
Against Female Winstar Rats
Tobacco plants are notably known for its pesticidal properties, particularly due to its
nicotine content. In this study, Nicotiana tabacum L. bio-oil was obtained using pyrolysis
technique. The safety of the bio-oil to be used as bioinsecticide was analyzed through acute oral
toxicity test by administering 5000 mg bio-oil/kg body weight of female winstar rats that were
analogous to humans. It was concluded that the bio-oil was not toxic due to absence of mortality
and no significant change in the body weight and behavior of the rats.
http://repository.uhamka.ac.id/745/1/Andjani_2019_IOP_Conf._Ser.__Earth_Environ._Sci._353_012047.pdf