Numlil, Khaira Rusdi
The excessive administration of antibiotics betalactame. especially third generation
cephalosporin widely for the treatment of infections in hospital was thought to be one
factor contributing to infection by bacteria Extented-Spectrum-Betalactamase (ESBL).
In hospital Persahabatan known that many third-generation cephalosporin antibiotic
used for the treatment of hospitalized patients. This study aimed to determine the effect
of beta-lactam antibiotics against infection by the emergence of ESBL-producing
bacteria at Persahabatan hospital Jakarta period January to March. 2013. This study was
case control study.involving patients with ESBL positive as case group and ESBL
negative as control group. Historical use of antibiotics during hospitalization in
Persahabatan traced in medical records retrospectively. Data were analyzed using chisquare
test
or
fisher
exact
test
followed
by
odd
ratio
calculation
and
calculate
the
DDD
(Defined
Daily
Dose)
to
determine
the
quantity
administration
of
antibiotic
betalactame.
A
total of 100 patients.50 patients are included into the case group and 50 into the
control group. Bivariate analysis showed that a history of antibiotic Betalactame use in
general (p = 0.357) was not a factor influencing the emergence of infections by ESBLproducing
bacteria. Historical administration of ceftriaxone (third-generation
cephalosporin) (p = 0.016. OR = 2.705. 95% CI = 1.197 to 6.113) were factors that
influence the emergence of infections by ESBL producing bacteria.